Dynamic Plantar Aesthesiometer
Manufacturer: Ugo Basile
Product code: 37550
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Description
Dynamic Plantar Aesthesiometer – For Automated Mechanical Stimulation and Allodynia
Description Of Dynamic Plantar Aesthesiometer – For Automated Mechanical Stimulation and Allodynia |
Background
- Von Frey filaments are still a productive way to evaluate behavioral responses of neuropathic pain in preclinical and clinical research.
- However, Von Frey tests are time consuming and subject to experimenter bias, and for this reason Ugo Basile developed a fully automated instrument
- Moreover, the application of the force is always perpendicular, with a preset amount of grams and at a predefined rate
- The Dynamic Plantar Aesthesiometer has been used in a variety of applications in nerve injury, from partial sciatic nerve ligation (PNL, to chronic constriction injury (CCI) and spinal nerve ligation (SNL) to screen phenotypes and drugs to treat allodynia and hyperalgesia
System components and main features
The Ugo Basile system comes complete with:
- A movable touch stimulator with standardized filament and angled mirror to facilitate paw targeting
- A touch-screen based electronic unit, which controls all the setting parameters, collects data and saves into USB stick for seamless export into CSV, Excel-compatible format
- A large testing grid surface with 5×5 mm square holes
- A modular set of animal enclosures to hold up to 6 rats and 12 mice
Additional features include:
- TTL outputs for start and stop
- Automatic or manual detection of paw withdrawal
- Analogue output is also available
- Filament approaching curve can be adjusted to provide a smoother or lighter first contact with the animal paw, before the force application ramp starts
| Feature | Benefit |
|---|---|
|
Fully automated force and force rate application |
Higher throughput and improved accuracy |
|
Automated scoring of paw withdrawal |
Higher throughput and improved accuracy, thanks to decrease in experimenter bias |
|
Large force range (0,5-100 grams) |
Flexibility for performing many types of experiments from severe allodynia to hyperalgesia |
|
Touch force and touch pause can be adjusted |
The way the probe approaches the paw can be changed, depending on paw sensitivity |
|
Touch screen and multiple data output (internal storage and CSV export) |
Data can be quickly saved in the electronic unit or on the USB stick for CSV export and further analysis |
|
Optional manual scoring of paw withdrawal |
Allows for scoring animals which present an unusual position of the paw, and do require the experimenter to visually score |
|
Painted metal grid and modular animal cages |
Works with rats and mice in high throughput (6 rats and 12 mice at the time) |
| General | |
|---|---|
| Read out and commands |
4,3 inches touch-screen (Resistive) |
| Power Requirements | Universal input 100-240 VAC, 50-60 Hz, 30W |
| Sound Level | Negligible |
| Operating Temperature |
10°C to 40°C; 5% to 95% RH (non-condensing) |
|
Operation |
|
| Force Range | 0.5 to 100 grams, in 0.1g steps |
| Force Increasing Rate (ramp) | Adjustable in the interval 0 to 50 seconds, in 1 s steps |
| Latency Time | Display in 0.1s steps |
|
Measurement Mode |
Automatic/Manual |
|
Start Experiment |
By Start button, push buttons or TTL input |
| Stop experiment |
By Stop button, push buttons, cut-off or TTL input |
| Data input | Experiment protocol |
|
Data export |
.csv format |
| TTL/IO | Start/Stop, Detection Mode, Force level |
| Calibration | Calibration Weights (5g, 50g, 100g) |
|
Physical |
|
| Total Weight | 10Kg |
| Shipping Weight | 13Kg |
| Dimensions (all parts) | 135 (w) x 40 (d) x 50 (h) cm (required space on table; all parts) |
| Packing Dimensions | 98x49x47 cm |
|
Physical animal enclosure setup (internal dimensions) |
|
| Mouse | 96mm x 96mm x 140mm (h) (max 12 animals) |
| Rat | 96mm x 196 mm x 140mm (h) (max 6 animals) |
| Fat Rat | 196mm x 196 mm x 140mm (h) (max 3 animals) |
|
Warranty |
|
| Warranty | Dynamic Plantar Aesthesiometer is covered by a 12-month warranty + 12 after product registration. |
| UB-Care | Additional UB-Care can be added for other 12 or 24 months |
